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dc.contributor.authorEspina-Benítez, Maríaes_ES
dc.contributor.authorAraújo, Liliaes_ES
dc.contributor.authorPrieto, Avismelsies_ES
dc.contributor.authorNavalón Montón, Alberto es_ES
dc.contributor.authorVílchez Quero, José Luis es_ES
dc.contributor.authorValera, Paolaes_ES
dc.contributor.authorZambrano, Anaes_ES
dc.contributor.authorDugas, Vincentes_ES
dc.date.accessioned2017-09-28T06:53:32Z
dc.date.available2017-09-28T06:53:32Z
dc.date.issued2017-07-07
dc.identifier.citationEspina-Benítez, M.; et al. Development of a New Microextraction Fiber Combined to On-Line Sample Stacking Capillary Electrophoresis UV Detection for Acidic Drugs Determination in Real Water Samples. International Journal of Environmental Research and Public Health, 14(7): 739 (2017). [http://hdl.handle.net/10481/47561]es_ES
dc.identifier.issn1660-4601
dc.identifier.urihttp://hdl.handle.net/10481/47561
dc.description.abstractA new analytical method coupling a (off-line) solid-phase microextraction with an on-line capillary electrophoresis (CE) sample enrichment technique was developed for the analysis of ketoprofen, naproxen and clofibric acid from water samples, which are known as contaminants of emerging concern in aquatic environments. New solid-phase microextraction fibers based on physical coupling of chromatographic supports onto epoxy glue coated needle were studied for the off-line preconcentration of these micropollutants. Identification and quantification of such acidic drugs were done by capillary zone electrophoresis (CZE) using ultraviolet diode array detection (DAD). Further enhancement of concentration sensitivity detection was achieved by on-line CE “acetonitrile stacking” preconcentration technique. Among the eight chromatographic supports investigated, Porapak Q sorbent showed higher extraction and preconcentration capacities. The screening of parameters that influence the microextraction process was carried out using a two-level fractional factorial. Optimization of the most relevant parameters was then done through a surface response three-factor Box-Behnken design. The limits of detection and limits of quantification for the three drugs ranged between 0.96 and 1.27 µg∙L−1 and 2.91 and 3.86 µg∙L−1, respectively. Recovery yields of approximately 95 to 104% were measured. The developed method is simple, precise, accurate, and allows quantification of residues of these micropollutants in Genil River water samples using inexpensive fibers.en_EN
dc.description.sponsorshipThe Council of Scientific and Humanistic Development (abbreviated as CONDES in Spanish). The University Sector Planning Office (abbreviated as OPSU in Spanish) and the Research Division of the Engineering Faculty.en_EN
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectAcid drugsen_EN
dc.subjectCapillary zone electrophoresisen_EN
dc.subjectSolid-phase microextractionen_EN
dc.subjectPorapak Qen_EN
dc.titleDevelopment of a New Microextraction Fiber Combined to On-Line Sample Stacking Capillary Electrophoresis UV Detection for Acidic Drugs Determination in Real Water Samplesen_EN
dc.typejournal articleen_EN
dc.rights.accessRightsopen accessen_EN
dc.identifier.doi10.3390/ijerph14070739


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