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dc.contributor.authorCózar Olmo, José Manuel 
dc.contributor.authorAptsiauri, Natalia
dc.contributor.authorTallada, Miguel
dc.contributor.authorGarrido Torres-Puchol, Federico 
dc.contributor.authorRuiz-Cabello, Francisco
dc.identifier.citationCózar, J.M; et al. Late pulmonary metastases of renal cell carcinoma immediately after post-transplantation immunosuppressive treatment: a case report. Journal of Medical Case Reports, 2: 111 (2008). []es_ES
dc.identifier.otherdoi: 10.1186/1752-1947-2-111
dc.identifier.otherPMCID: PMC2359763
dc.description.abstractIntroduction We report a case of pulmonary metastatic recurrence of renal adenocarcinoma soon after radical nephrectomy that was followed by renal transplant and immunosuppressive medication. Increased risk of metastatic recurrence of renal cell carcinoma should be considered in the immediate post-transplant period when immunosuppressive medication is administered, even if nephrectomy had been performed many years earlier.es_ES
dc.description.abstractCase presentation In 1986 the patient demonstrated renal insufficiency secondary to mesangial glomerulonephritis. In 1992 he underwent left side radical nephrectomy with histopathological diagnosis of clear cell adenocarcinoma. Mesangial glomerulonephritis in the remaining right kidney progressed to end-stage renal failure. In October 2000 he received a kidney transplant from a cadaver and commenced immunosuppressive medication. Two months later, several nodules were found in his lungs, which were identified as metastases from the primary renal tumor that had been removed with the diseased kidney 8 years earlier.es_ES
dc.description.abstractConclusion Recurrence of renal cell carcinoma metastases points to tumor dormancy and reflects a misbalance between effective tumor immune surveillance and immune escape. This case demonstrates that a state of tumor dormancy can be interrupted soon after administration of immunosuppressant medication.es_ES
dc.description.sponsorshipThis work was partially supported by the Fondo de Investigaciones Sanitarias (PI 02/0175), the plan Andaluz de Investigacion, and the Instituto de Salud Carlos III-Red de centros de Cancer, Spain.es_ES
dc.publisherBiomed Centrales_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.subjectRenal carcinomaes_ES
dc.subjectCell cyclees_ES
dc.subjectInflammation es_ES
dc.titleLate pulmonary metastases of renal cell carcinoma immediately after post-transplantation immunosuppressive treatment: a case reportes_ES

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