Semisynthesis of Forsyshiyanine A and a Derivative with Significant Anti-Pancreatic Cancer Activity

Rfaish, Saad Y.; Fernández Vargas, Antonio Jesús; Ramos Cobos, María Del Carmen; Mackenzie, Thomas A.; Justicia Ladrón De Guevara, José; Chahboun Karimi, Rachid

doi:10.1021/acs.jnatprod.5c01178

semisynthesis-of-forsyshiyanine-a-and-a-derivative-with-significant-anti-pancreatic-cancer-activity.pdf (2.284Mb)

Identificadores

URI: https://hdl.handle.net/10481/107898

DOI: 10.1021/acs.jnatprod.5c01178

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Editorial

American Chemical Society

Fecha

2025-11-03

Referencia bibliográfica

Rfaish, S. Y., Fernández, A., Ramos, M. C., Mackenzie, T. A., Justicia, J., & Chahboun, R. (2025). Semisynthesis of forsyshiyanine A and a derivative with significant anti-pancreatic cancer activity. Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.5c01178

Patrocinador

EDER - Junta de Andalucía - Consejería de Universidad, Investigación e Innovación (projects, grant number C-EXP053-UGR23 and C-EXP-087-UGR23); Universidad de Granada / CBUA (Open access charge)

Resumen

Forsyshiyanine A (8), a trinorditerpene alkaloid isolated from Forsythia suspensa exhibiting in vitro anti-inflammatory and antiviral activities, has been synthesized for the first time from trans-communic acid (12a) and labdane cupressic acid (13). Furthermore, a series of derivatives were efficiently prepared and screened for cytotoxic activities against five human tumoral cell lines. Derivative 25 showed cytotoxicity (IC50 = 6.5 μM) against the Mia PaCa-2 pancreatic cancer cell line, making it an interesting candidate for future structure−activity relationship (SAR) investigations.

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