Semisynthesis of Forsyshiyanine A and a Derivative with Significant Anti-Pancreatic Cancer Activity Rfaish, Saad Y. Fernández Vargas, Antonio Jesús Ramos Cobos, María Del Carmen Mackenzie, Thomas A. Justicia Ladrón De Guevara, José Chahboun Karimi, Rachid Forsyshiyanine A (8), a trinorditerpene alkaloid isolated from Forsythia suspensa exhibiting in vitro anti-inflammatory and antiviral activities, has been synthesized for the first time from trans-communic acid (12a) and labdane cupressic acid (13). Furthermore, a series of derivatives were efficiently prepared and screened for cytotoxic activities against five human tumoral cell lines. Derivative 25 showed cytotoxicity (IC50 = 6.5 μM) against the Mia PaCa-2 pancreatic cancer cell line, making it an interesting candidate for future structure−activity relationship (SAR) investigations. 2025-11-10T11:59:35Z 2025-11-10T11:59:35Z 2025-11-03 journal article Rfaish, S. Y., Fernández, A., Ramos, M. C., Mackenzie, T. A., Justicia, J., & Chahboun, R. (2025). Semisynthesis of forsyshiyanine A and a derivative with significant anti-pancreatic cancer activity. Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.5c01178 https://hdl.handle.net/10481/107898 10.1021/acs.jnatprod.5c01178 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional American Chemical Society