@misc{10481/107898,
year = {2025},
month = {11},
url = {https://hdl.handle.net/10481/107898},
abstract = {Forsyshiyanine A (8), a trinorditerpene alkaloid
isolated from Forsythia suspensa exhibiting in vitro anti-inflammatory
and antiviral activities, has been synthesized for the first time from
trans-communic acid (12a) and labdane cupressic acid (13).
Furthermore, a series of derivatives were efficiently prepared and
screened for cytotoxic activities against five human tumoral cell
lines. Derivative 25 showed cytotoxicity (IC50 = 6.5 μM) against
the Mia PaCa-2 pancreatic cancer cell line, making it an interesting
candidate for future structure−activity relationship (SAR) investigations.},
organization = {EDER - Junta de Andalucía - Consejería de Universidad, Investigación e Innovación (projects, grant number C-EXP053-UGR23 and C-EXP-087-UGR23)},
organization = {Universidad de Granada / CBUA (Open access charge)},
publisher = {American Chemical Society},
title = {Semisynthesis of Forsyshiyanine A and a Derivative with Significant Anti-Pancreatic Cancer Activity},
doi = {10.1021/acs.jnatprod.5c01178},
author = {Rfaish, Saad Y. and Fernández Vargas, Antonio Jesús and Ramos Cobos, María Del Carmen and Mackenzie, Thomas A. and Justicia Ladrón De Guevara, José and Chahboun Karimi, Rachid},
}