Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders

Abstract

Aim: The development and optimization of Ketorolac tromethamine-loadedpolylactic-co-glycolic acid nanoparticles (KT-NPs) for the treatment of inflammatory processes of the eye. Materials & methods: KT-NPs weredeveloped by factorial design and characterized by assessing theirphysicochemical properties. Biopharmaceutical behavior studies, oculartolerance, anti-inflammatory efficacy and bioavailability tests were performedon pigs. Results: Optimized KT-NPs of 112 nm, narrow distribution withencapsulation efficiency near 100% were obtained. KT release followed theWeibull model and there was significantly greater retention in the cornea andsclera than in the commercial reference. KT-NPs showed no signs of ocularirritancy and similar anti-inflammatory efficacy to the commercial reference. Conclusion: KT-NPs were a suitable alternative for the treatment ofinflammatory disorders of the anterior and posterior segments of the eye asan alternative to conventional topical formulations.