@misc{10481/106724,
year = {2021},
month = {2},
url = {https://hdl.handle.net/10481/106724},
abstract = {Aim: The development and optimization of Ketorolac tromethamine-loadedpolylactic-co-glycolic acid nanoparticles (KT-NPs) for the treatment of inflammatory processes of the eye.
Materials & methods: KT-NPs weredeveloped by factorial design and characterized by assessing theirphysicochemical properties. Biopharmaceutical behavior studies, oculartolerance, anti-inflammatory efficacy and bioavailability tests were performedon pigs.
Results: Optimized KT-NPs of 112 nm, narrow distribution withencapsulation efficiency near 100% were obtained. KT release followed theWeibull model and there was significantly greater retention in the cornea andsclera than in the commercial reference. KT-NPs showed no signs of ocularirritancy and similar anti-inflammatory efficacy to the commercial reference.
Conclusion: KT-NPs were a suitable alternative for the treatment ofinflammatory disorders of the anterior and posterior segments of the eye asan alternative to conventional topical formulations.},
organization = {Ministerio de Ciencia e Innovación (MAT201459134R)},
publisher = {Future Medicine},
keywords = {anti-inflammatory efficacy},
keywords = {Factorial design},
keywords = {ketorolac tromethamine},
keywords = {nanoparticles},
keywords = {ocular administration},
title = {Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders},
doi = {10.2217/nnm-2020-0403},
author = {Mallandrich, Mireia and Calpena, Ana C. and Clares Naveros, Beatriz and Parra, Alexander and García, María Luisa and Soriano, José L. and Fernández, Francisco},
}