Early heart and skeletal muscle mitochondrial response to a moderate hypobaric hypoxia environment
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Aragón Vela, Jerónimo; Casuso, Rafael A.; Sagrera Aparisi, Ana; Plaza Díaz, Julio Ramón; Rueda-Robles, Ascensión; Hidalgo Gutiérrez, Agustín; López García, Luis Carlos; Rodriguez-Carrillo, Andrea; Enriquez, José Antonio; Cogliati, Sara; Rodríguez Huertas, Jesús FranciscoEditorial
Wiley Online Library
Materia
heart mitochondria moderate hypobaric hypoxia
Date
2024-04-17Referencia bibliográfica
Aragón Vidal, J. et. al. J Physiol 602.21 (2024) pp 5631–5641. [https://doi.org/10.1113/JP285516]
Sponsorship
Grant PID2022-140453OB-I00 financed by MICIU/AEI/10.13039/501100011033 and the FEDER, UE; ‘Ramón y Cajal fellowship 23013-2017’ founded by MCIN/AEI/10.13039/501100011033 and ‘El FSE invierte en tu futuro’; Grant PID2020-114054RA-I00 1001100482 founded by MCIN/AEI/10.13039/501100011033; Grant PID2021-126788OB-I00 from the MICIU/AEI/10.13039/501100011033, Spain, and the ERDF/EU; Marie S. Curie Global Fellowships within the European Union research and innovation framework programme Horizon Europe (2021-2027) (AHG)Abstract
In eukaryotic cells, aerobic energy is produced by mitochondria through oxygen uptake.
However, little is known about the early mitochondrial responses to moderate hypobaric hypoxia
(MHH) in highlymetabolic active tissues. Here, we describe the mitochondrial responses to acute MHH in the heart and skeletalmuscle. Rats were randomly allocated into a normoxia control group
(n = 10) and a hypoxia group (n = 30), divided into three groups (0, 6, and 24 h post-MHH). The
normoxia situation was recapitulated at the University of Granada, at 662 m above sea level. The
MHH situation was performed at the High-Performance Altitude Training Centre of Sierra Nevada
located inGranada at 2320mabove sea level.We found a significant increase inmitochondrial supercomplex
assembly in the heart as soon as the animals reached 2320mabove sea level and their levels
are maintained 24 h post-exposure, but not in skeletal muscle. Furthermore, in skeletal muscle, at 0
and 6 h, therewas increased dynamin-related protein 1 (Drp1) expression and a significant reduction
inMitofusin 2. In conclusion,mitochondria from themuscle and heart respond differently toMHH:
mitochondrial supercomplexes increase in the heart, whereas, in skeletal muscle, the mitochondrial
pro-fission response is trigged. Considering that skeletal muscle was not actively involved in the
ascent when the heart was beating faster to compensate for the hypobaric, hypoxic conditions, we
speculate that the different responses toMHH are a result of the different energetic requirements of
the tissues upon MHH.