@misc{10481/98698,
year = {2024},
month = {4},
url = {https://hdl.handle.net/10481/98698},
abstract = {In eukaryotic cells, aerobic energy is produced by mitochondria through oxygen uptake.
However, little is known about the early mitochondrial responses to moderate hypobaric hypoxia
(MHH) in highlymetabolic active tissues. Here, we describe the mitochondrial responses to acute MHH in the heart and skeletalmuscle. Rats were randomly allocated into a normoxia control group
(n = 10) and a hypoxia group (n = 30), divided into three groups (0, 6, and 24 h post-MHH). The
normoxia situation was recapitulated at the University of Granada, at 662 m above sea level. The
MHH situation was performed at the High-Performance Altitude Training Centre of Sierra Nevada
located inGranada at 2320mabove sea level.We found a significant increase inmitochondrial supercomplex
assembly in the heart as soon as the animals reached 2320mabove sea level and their levels
are maintained 24 h post-exposure, but not in skeletal muscle. Furthermore, in skeletal muscle, at 0
and 6 h, therewas increased dynamin-related protein 1 (Drp1) expression and a significant reduction
inMitofusin 2. In conclusion,mitochondria from themuscle and heart respond differently toMHH:
mitochondrial supercomplexes increase in the heart, whereas, in skeletal muscle, the mitochondrial
pro-fission response is trigged. Considering that skeletal muscle was not actively involved in the
ascent when the heart was beating faster to compensate for the hypobaric, hypoxic conditions, we
speculate that the different responses toMHH are a result of the different energetic requirements of
the tissues upon MHH.},
organization = {Grant PID2022-140453OB-I00 financed
by MICIU/AEI/10.13039/501100011033 and the FEDER, UE},
organization = {‘Ramón y Cajal fellowship
23013-2017’ founded by MCIN/AEI/10.13039/501100011033
and ‘El FSE invierte en tu futuro’},
organization = {Grant PID2020-114054RA-I00 1001100482
founded by MCIN/AEI/10.13039/501100011033},
organization = {Grant PID2021-126788OB-I00 from
the MICIU/AEI/10.13039/501100011033, Spain, and the
ERDF/EU},
organization = {Marie S. Curie
Global Fellowships within the European Union research
and innovation framework programme Horizon Europe
(2021-2027) (AHG)},
publisher = {Wiley Online Library},
keywords = {heart},
keywords = {mitochondria},
keywords = {moderate hypobaric hypoxia},
title = {Early heart and skeletal muscle mitochondrial response to a moderate hypobaric hypoxia environment},
doi = {10.1113/JP285516},
author = {Aragón Vela, Jerónimo and Casuso, Rafael A. and Sagrera Aparisi, Ana and Plaza Díaz, Julio Ramón and Rueda-Robles, Ascensión and Hidalgo Gutiérrez, Agustín and López García, Luis Carlos and Rodriguez-Carrillo, Andrea and Enriquez, José Antonio and Cogliati, Sara and Rodríguez Huertas, Jesús Francisco},
}