Effectiveness of non-instrumental early mobilization to reduce the incidence of deep vein thrombosis in hospitalized patients: A systematic review and meta-analysis
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Raya Benítez, Julia; Heredia-Ciuró, Alejandro; Calvache Mateo, Andrés; Martín-Núñez, Javier; Valenza Peña, Geraldine; López López, Laura; Valenza, Marie CarmenEditorial
Elsevier
Materia
Deep vein thrombosis Early mobilization Patient admission
Date
2024-10-16Referencia bibliográfica
Raya Benítez, J. et. al. International Journal of Nursing Studies 161 (2025) 104917. [https://doi.org/10.1016/j.ijnurstu.2024.104917]
Sponsorship
Spanish Ministry of Education [grant numbers FPU:19/02609, FPU:20/01670, FPU:21/00451]; Universidad de Granada/CBUAAbstract
Background: Deep vein thrombosis (DVT) poses a significant health risk, particularly in hospitalized patients with
multiple risk factors (cigarette smoking, hypertension, diabetes and obesity). Despite advances in treatment, DVT
remains a prevalent complication of hospitalization.
Objective: To assess the effectiveness of non-instrumental mobilization in hospitalized patients at high risk of
DVT, exploring the challenges and variations in intervention protocols.
Design: Systematic review and meta-analysis.
Setting(s): Not applicable.
Participants: Hospitalized patients at risk of deep vein thrombosis.
Methods: A systematic search of three databases was conducted from interception to September 2023 for randomized
controlled trials. This study was registered in PROSPERO (CRD42023460485). This study was conducted
according to PRISMA 2020 statement. Two authors independently screened the studies and extracted the
data. The quality of the studies was evaluated using the Downs and Black checklist and GRADE system. The
amount of evidence certainty was assessed using the Cochrane Risk of Bias Assessment tool. Meta-analysis was
performed addressing the incidence of deep vein thrombosis during hospitalization.
Results: 7 studies were eligible for inclusion which included a total of 1774 participants. Interventions ranged
from active and passive ankle exercises to walking. Meta-analysis demonstrated a significant overall effect in
favor of non-instrumental early mobilization compared to usual care (RR = 0.55; 95 % CI = 0.41, 0.73; p <
0.0001). Subgroup analysis comparing type of mobilization revealed significant effects for global (RR = 0.54; 95
% CI = 0.38, 0.78; p = 0.001) and remote mobilization (RR = 0.25; 95 % CI = 0.07, 0.86; p = 0.03).
Conclusions: Non-instrumental early mobilization is beneficial in reducing the incidence of deep vein thrombosis
in hospitalized patients.