Exploring the Impact of Resistance Training at Moderate Altitude on Metabolic Cytokines in Humans: Implications for Adipose Tissue Dynamics
Metadatos
Mostrar el registro completo del ítemAutor
Pérez Regalado, Sergio; León, Josefa; Padial Puche, Paulino; Benavente Bardera, Cristina; De Sousa Fernandes Alcobia de Almeida, Filipa; Bonitch-Góngora, Juan; de la Fuente, Blanca; Feriche Fernández-Castanys, María BelénEditorial
MDPI
Materia
altitude resistance training metabolism
Fecha
2024-10-24Referencia bibliográfica
Pérez REgalado, S. et. al. Int. J. Mol. Sci. 2024, 25, 11418. [https://doi.org/10.3390/ijms252111418]
Patrocinador
SpanishMinistry of Science, Innovation and Universities [grant number PGC2018-097388-B-I00-MCI/AEI/FEDER, UE]; FEDER/Junta de Andalucía- Ministry of Economic Transformation, Industry, Knowledge, and Universities [grant number B-CTS-374-UGR20]Resumen
Hypobaric hypoxia (HH) limits oxygen supply to tissues and increases metabolic demands,
especially during exercise. We studied the influence of HH exposure on the subcutaneous
adipose tissue (SAT) thickness and circulating metabolic-related cytokines levels after a resistance
training (RT) program. Twenty trained men participated in a traditional hypertrophy RT for
8 weeks (three sessions/week) under intermittent terrestrial HH (2320 m) or normoxia (N, 690 m)
conditions. Before, at week 6, and after the RT, SAT, and vastus lateralis (VL) muscle thickness
were measured by ultrasound. Blood samples were taken to analyse serum cytokines (IL-6, IL-15,
irisin, and myostatin) by multiplex immunoassay. Our findings revealed a moderate reduction in
IL-6 and irisin in HH following the RT (ES < −0.64; p < 0.05). Additionally, RT in HH promoted
serum IL-15 release (ES = 0.890; p = 0.062), which exhibited a trivial inverse association with the
reductions observed on SAT (−17.69%; p < 0.001) compared with N. RT in HH explained ~50% of
SAT variance (p < 0.001). These results highlight the benefit of stressor factors linked to RT in HH
on SAT through the modulation of serum metabolic cytokine profiles, suggesting a potential effect
on overall body composition.