Albumin-covered lipid nanocapsules exhibit enhanced uptake performance by breast-tumor cells
Metadatos
Mostrar el registro completo del ítemAutor
Galisteo González, Francisco; Molina Bolívar, José Antonio; Navarro Marchal, Saul Abenhamar; Boulaiz Tassi, Houria; Aguilera Garrido, Aixa María; Ramírez, Alberto; Marchal Corrales, Juan AntonioEditorial
Elsevier
Materia
Cellular uptake Curcumin Drug-delivery system Olive-oil nanocapsules
Fecha
2018-05Referencia bibliográfica
F. Galisteo-González et al. Albumin-covered lipid nanocapsules exhibit enhanced uptake performance by breast-tumor cells. Colloids and Surfaces B: Biointerfaces 165 (2018) 103–110. doi: 10.1016/j.colsurfb.2018.02.024
Patrocinador
Projects MAT2015-62644-C2-1-R, MAT2015-62644-C2-2-RResumen
Liquid lipid nanocapsules (LLN) represent a promising new generation of drug-delivery systems. They can carry hydrophobic drugs in their oily core, but the composition and structure of the surrounding protective shell determine their capacity to survive in the circulatory system and to achieve their goal: penetrate tumor cells. Here, we present a study of LLN covered by the protein human serum albumin (HSA) and loaded with curcumin as a hydrophobic model drug. A cross-linking procedure was performed to further strengthen the protective protein layer. Physicochemical properties and release kinetics of the nanocapsules were investigated, and cellular uptake and killing capacity were evaluated on the human breast-cancer line MCF-7. The nanocapsules exhibited a half maximal inhibitory concentration (IC50) capacity similar to that of free curcumin, but avoiding problems associated with excipients, and displayed an outstanding uptake performance, entering cells massively in less than 1 min.