@misc{10481/94729,
year = {2018},
month = {5},
url = {https://hdl.handle.net/10481/94729},
abstract = {Liquid lipid nanocapsules (LLN) represent a promising new generation of drug-delivery systems. They can carry hydrophobic drugs in their oily core, but the composition and structure of the surrounding protective shell determine their capacity to survive in the circulatory system and to achieve their goal: penetrate tumor cells. Here, we present a study of LLN covered by the protein human serum albumin (HSA) and loaded with curcumin as a hydrophobic model drug. A cross-linking procedure was performed to further strengthen the protective protein layer. Physicochemical properties and release kinetics of the nanocapsules were investigated, and cellular uptake and killing capacity were evaluated on the human breast-cancer line MCF-7. The nanocapsules exhibited a half maximal inhibitory concentration (IC50) capacity similar to that of free curcumin, but avoiding problems associated with excipients, and displayed an outstanding uptake performance, entering cells massively in less than 1 min.},
organization = {Projects MAT2015-62644-C2-1-R, MAT2015-62644-C2-2-R},
publisher = {Elsevier},
keywords = {Cellular uptake},
keywords = {Curcumin},
keywords = {Drug-delivery system},
keywords = {Olive-oil nanocapsules},
title = {Albumin-covered lipid nanocapsules exhibit enhanced uptake performance by breast-tumor cells},
doi = {10.1016/j.colsurfb.2018.02.024},
author = {Galisteo González, Francisco and Molina Bolívar, José Antonio and Navarro Marchal, Saul Abenhamar and Boulaiz Tassi, Houria and Aguilera Garrido, Aixa María and Ramírez, Alberto and Marchal Corrales, Juan Antonio},
}