Possible Role of Cytomegalovirus in Gastric Cancer Development and Recurrent Macrolide-Resistant Campylobacter jejuni Infection in Common Variable Immunodeficiency: A Case Report and Literature Discussion
Metadatos
Mostrar el registro completo del ítemAutor
Díaz Alberola, Irene; Espuch Oliver, Andrea; Fernández-Segovia, Francisco; López Nevot, Miguel ÁngelEditorial
MDPI
Materia
Common variable immunodeficiency CVID Infections
Fecha
2024-05-27Referencia bibliográfica
Díaz Alberola, I. et. al. Microorganisms 2024, 12, 1078. [https://doi.org/10.3390/microorganisms12061078]
Patrocinador
Palex Medical S.AResumen
Common variable immunodeficiency (CVID) is the most common symptomatic immunodeficiency
in adults. It comprises a group of syndromes whose etiology involves genetic, epigenetic,
microbiota, and environmental factors. We present the case of a 46-year-old Caucasian male patient
with CVID and an immune dysregulation phenotype. The particular elements of the case consisted
of an atypical clinical course, which undoubtedly demonstrates the great variability of clinical
manifestations that these types of patients can suffer from, including bacterial and viral infections,
autoimmune phenomena, and neoplasia. Notably, the patient suffered from recurrent gastrointestinal
infection with macrolide-resistant Campylobacter jejuni and gastroduodenal disease and viraemia
by cytomegalovirus (CMV). In addition, CMV was postulated as the main pro-oncogenic factor
contributing to the development of early-onset intestinal-type gastric adenocarcinoma, for which
the patient underwent gastrectomy. The patient’s evolution was difficult, but finally, as a result of
the multidisciplinary approach, clinical stabilization and improvement in his quality of life were
achieved. Based on our brief literature review, this is the first reported case of this clinical complexity.
Our experience could help with the management of future patients with CVID and may also update
current epidemiological data on CVID.