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Single-Molecule Identification of the Isomers of a Lipidic Antibody Activator
dc.contributor.author | Mallada, Benjamin | |
dc.contributor.author | Villalobos Romero, Federico | |
dc.contributor.author | Donoso, Beatriz | |
dc.contributor.author | Casares López, Raquel | |
dc.contributor.author | Longhi, Giovanna | |
dc.contributor.author | Mendieta-Moreno, Jesús I. | |
dc.contributor.author | Jiménez Martín, Alejandro | |
dc.contributor.author | Haidour, Ali | |
dc.contributor.author | Seepersaud, Ravin | |
dc.contributor.author | Rajagopal, Lakshmi | |
dc.contributor.author | de la Torre, Bruno | |
dc.contributor.author | Millán Delgado, Alba | |
dc.contributor.author | Cuerva, Juan M. | |
dc.date.accessioned | 2024-07-26T10:52:52Z | |
dc.date.available | 2024-07-26T10:52:52Z | |
dc.date.issued | 2024-06-27 | |
dc.identifier.citation | Mallada, B. et. al. J. Phys. Chem. Lett. 2024, 15, 6935−6942. [https://doi.org/10.1021/acs.jpclett.4c00164] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/93522 | |
dc.description.abstract | Molecular structural elucidation can be accomplished by different techniques, such as nuclear magnetic resonance or X-ray diffraction. However, the former does not give information about the three-dimensional atomic arrangement, and the latter needs crystallizable solid samples. An alternative is direct, real-space visualization of the molecules by cryogenic scanning tunneling microscopy (STM). This technique is usually limited to thermally robust molecules because an annealing step is required for sample deposition. A landmark development has been the coupling of STM with electrospray deposition (ESD), which smooths the process and widens the scope of the visualization technique. In this work, we present the on-surface characterization of air-, light-, and temperature-sensitive rhamnopolyene with relevance in molecular biology. Supported by theoretical calculations, we characterize two isomers of this flexible molecule, confirming the potential of the technique to inspect labile, non-crystallizable compounds. | es_ES |
dc.description.sponsorship | National Institutes of Health (U.S.A., R01AI167421) | es_ES |
dc.description.sponsorship | FEDER/Junta de Andalucía−Consejería de Transformación Económica, Industria, Conocimiento y Universidades (Spain, Grants B-FQM-130-UGR20 and P20_00028) | es_ES |
dc.description.sponsorship | Ministerio de Universidades (Spain, FPU18/05938) | es_ES |
dc.description.sponsorship | Czech Science Foundation (23-06781M) and the CzechNanoLab Research Infrastructure supported by the Ministry of Education, Youth and Sports of the Czech Republic (MEYS CR, LM2023051) | es_ES |
dc.description.sponsorship | Universidad de Granada / CBUA | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | ACS Publications | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Single-Molecule Identification of the Isomers of a Lipidic Antibody Activator | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1021/acs.jpclett.4c00164 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |