Natural Products Derived from Marine Sponges with Antitumor Potential against Lung Cancer: A Systematic Review
Metadatos
Mostrar el registro completo del ítemAutor
Ortigosa Palomo, Alba; Quiñonero Muñoz, Francisco José; Ortiz Quesada, Raúl; Sarabia, Francisco; Prados Salazar, José Carlos; Melguizo Alonso, ConsolaciónEditorial
MDPI
Materia
Marine sponge Bioactive compounds Antitumor
Fecha
2024-02-23Referencia bibliográfica
Ortigosa-Palomo, A.; Quiñonero, F.; Ortiz, R.; Sarabia, F.; Prados, J.; Melguizo, C. Natural Products Derived from Marine Sponges with Antitumor Potential against Lung Cancer: A Systematic Review. Mar. Drugs 2024, 22, 101. https://doi.org/10.3390/md22030101
Patrocinador
Granada University (P20B-2023 from Programa del Plan Propio de Investigación)Resumen
Non-small-cell lung cancer (NSCLC), the most commonly diagnosed cancer and the leading
cause of cancer-related death worldwide, has been extensively investigated in the last decade in
terms of developing new therapeutic options that increase patient survival. In this context, marine
animals are a source of new, interesting bioactive molecules that have been applied to the treatment
of different types of cancer. Many efforts have been made to search for new therapeutic strategies to
improve the prognosis of lung cancer patients, including new bioactive compounds and cytotoxic
drugs from marine sponges. Their antitumoral effect can be explained by several cellular and
molecular mechanisms, such as modulation of the cell cycle or induction of apoptosis. Thus, this
systematic review aims to summarize the bioactive compounds derived from marine sponges and the
mechanisms by which they show antitumor effects against lung cancer, exploring their limitations
and the challenges associated with their discovery. The search process was performed in three
databases (PubMed, SCOPUS, andWeb of Science), yielding a total of 105 articles identified in the
last 10 years, and after a screening process, 33 articles were included in this systematic review. The
results showed that these natural sponge-derived compounds are a valuable source of inspiration for
the development of new drugs. However, more research in this field is needed for the translation of
these novel compounds to the clinic.