<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/91810">
      <dc:title>Natural Products Derived from Marine Sponges with Antitumor Potential against Lung Cancer: A Systematic Review</dc:title>
      <dc:creator>Ortigosa Palomo, Alba</dc:creator>
      <dc:creator>Quiñonero Muñoz, Francisco José</dc:creator>
      <dc:creator>Ortiz Quesada, Raúl</dc:creator>
      <dc:creator>Sarabia, Francisco</dc:creator>
      <dc:creator>Prados Salazar, José Carlos</dc:creator>
      <dc:creator>Melguizo Alonso, Consolación</dc:creator>
      <dc:subject>Marine sponge</dc:subject>
      <dc:subject>Bioactive compounds</dc:subject>
      <dc:subject>Antitumor</dc:subject>
      <dc:description>Non-small-cell lung cancer (NSCLC), the most commonly diagnosed cancer and the leading&#xd;
cause of cancer-related death worldwide, has been extensively investigated in the last decade in&#xd;
terms of developing new therapeutic options that increase patient survival. In this context, marine&#xd;
animals are a source of new, interesting bioactive molecules that have been applied to the treatment&#xd;
of different types of cancer. Many efforts have been made to search for new therapeutic strategies to&#xd;
improve the prognosis of lung cancer patients, including new bioactive compounds and cytotoxic&#xd;
drugs from marine sponges. Their antitumoral effect can be explained by several cellular and&#xd;
molecular mechanisms, such as modulation of the cell cycle or induction of apoptosis. Thus, this&#xd;
systematic review aims to summarize the bioactive compounds derived from marine sponges and the&#xd;
mechanisms by which they show antitumor effects against lung cancer, exploring their limitations&#xd;
and the challenges associated with their discovery. The search process was performed in three&#xd;
databases (PubMed, SCOPUS, andWeb of Science), yielding a total of 105 articles identified in the&#xd;
last 10 years, and after a screening process, 33 articles were included in this systematic review. The&#xd;
results showed that these natural sponge-derived compounds are a valuable source of inspiration for&#xd;
the development of new drugs. However, more research in this field is needed for the translation of&#xd;
these novel compounds to the clinic.</dc:description>
      <dc:date>2024-05-15T10:04:33Z</dc:date>
      <dc:date>2024-05-15T10:04:33Z</dc:date>
      <dc:date>2024-02-23</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Ortigosa-Palomo, A.; Quiñonero, F.; Ortiz, R.; Sarabia, F.; Prados, J.; Melguizo, C. Natural Products Derived from Marine Sponges with Antitumor Potential against Lung Cancer: A Systematic Review. Mar. Drugs 2024, 22, 101. https://doi.org/10.3390/md22030101</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/91810</dc:identifier>
      <dc:identifier>10.3390/md22030101</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>