An in vitro experimental investigation of oscillatory flow in the cerebral aqueduct
Metadatos
Mostrar el registro completo del ítemAutor
Sincomb, S.; Moral Pulido, Francisco; Campos, O.; Martínez Bazán, Jesús Carlos; Haughton, V.; Sánchez, A.L.Editorial
Elsevier
Materia
Cerebrospinal fluid Cerebral aqueduct Interventricular pressure
Fecha
2024-01-25Referencia bibliográfica
S. Sincomb, F. Moral-Pulido, O. Campos, C. Martínez-Bazán, V. Haughton, A.L. Sánchez, An in vitro experimental investigation of oscillatory flow in the cerebral aqueduct, European Journal of Mechanics - B/Fluids, Volume 105, 2024, Pages 180-191, ISSN 0997-7546, https://doi.org/10.1016/j.euromechflu.2024.01.010. (https://www.sciencedirect.com/science/article/pii/S0997754624000189)
Patrocinador
National Institutes of Health/ National Institute of Neurological Diseases and Stroke through contract # 1R01NS120343-01Resumen
This in vitro study aims at clarifying the relation between the oscillatory flow of cerebrospinal fluid (CSF) in
the cerebral aqueduct, a narrow conduit connecting the third and fourth ventricles, and the corresponding
interventricular pressure difference. Dimensional analysis is used in designing an anatomically correct scaled
model of the aqueduct flow, with physical similarity maintained by adjusting the flow frequency and the
properties of the working fluid. The time-varying pressure difference across the aqueduct corresponding
to a given oscillatory flow rate is measured in parametric ranges covering the range of flow conditions
commonly encountered in healthy subjects. Parametric dependences are delineated for the time-averaged
pressure fluctuations and for the phase lag between the transaqueductal pressure difference and the flow
rate, both having clinical relevance. The results are validated through comparisons with predictions obtained
with a previously derived computational model. The parametric quantification in this study enables the
derivation of a simple formula for the relation between the transaqueductal pressure and the stroke volume.
This relationship can be useful in the quantification of transmantle pressure differences based on non-invasive
magnetic-resonance-velocimetry measurements of aqueduct flow for investigation of CSF-related disorders.