<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/91656">
      <dc:title>An in vitro experimental investigation of oscillatory flow in the cerebral aqueduct</dc:title>
      <dc:creator>Sincomb, S.</dc:creator>
      <dc:creator>Moral Pulido, Francisco</dc:creator>
      <dc:creator>Campos, O.</dc:creator>
      <dc:creator>Martínez Bazán, Jesús Carlos</dc:creator>
      <dc:creator>Haughton, V.</dc:creator>
      <dc:creator>Sánchez, A.L.</dc:creator>
      <dc:subject>Cerebrospinal fluid</dc:subject>
      <dc:subject>Cerebral aqueduct</dc:subject>
      <dc:subject>Interventricular pressure</dc:subject>
      <dc:description>This in vitro study aims at clarifying the relation between the oscillatory flow of cerebrospinal fluid (CSF) in&#xd;
the cerebral aqueduct, a narrow conduit connecting the third and fourth ventricles, and the corresponding&#xd;
interventricular pressure difference. Dimensional analysis is used in designing an anatomically correct scaled&#xd;
model of the aqueduct flow, with physical similarity maintained by adjusting the flow frequency and the&#xd;
properties of the working fluid. The time-varying pressure difference across the aqueduct corresponding&#xd;
to a given oscillatory flow rate is measured in parametric ranges covering the range of flow conditions&#xd;
commonly encountered in healthy subjects. Parametric dependences are delineated for the time-averaged&#xd;
pressure fluctuations and for the phase lag between the transaqueductal pressure difference and the flow&#xd;
rate, both having clinical relevance. The results are validated through comparisons with predictions obtained&#xd;
with a previously derived computational model. The parametric quantification in this study enables the&#xd;
derivation of a simple formula for the relation between the transaqueductal pressure and the stroke volume.&#xd;
This relationship can be useful in the quantification of transmantle pressure differences based on non-invasive&#xd;
magnetic-resonance-velocimetry measurements of aqueduct flow for investigation of CSF-related disorders.</dc:description>
      <dc:date>2024-05-10T11:50:43Z</dc:date>
      <dc:date>2024-05-10T11:50:43Z</dc:date>
      <dc:date>2024-01-25</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>S. Sincomb, F. Moral-Pulido, O. Campos, C. Martínez-Bazán, V. Haughton, A.L. Sánchez, An in vitro experimental investigation of oscillatory flow in the cerebral aqueduct, European Journal of Mechanics - B/Fluids, Volume 105, 2024, Pages 180-191, ISSN 0997-7546, https://doi.org/10.1016/j.euromechflu.2024.01.010. (https://www.sciencedirect.com/science/article/pii/S0997754624000189)</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/91656</dc:identifier>
      <dc:identifier>10.1016/j.euromechflu.2024.01.010</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 Internacional</dc:rights>
      <dc:publisher>Elsevier</dc:publisher>
   </ow:Publication>
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