Multiclass Determination of Endocrine-Disrupting Chemicals in Meconium: First Evidence of Perfluoroalkyl Substances in This Biological Compartment
Metadatos
Mostrar el registro completo del ítemAutor
Domínguez Liste, Aritz; De Haro Romero, Teresa; Quesada Jiménez, Raquel; Pérez Cantero, Ainhoa; Peinado, Francisco Manuel; Ballesteros García, Óscar; Vela Soria, FernandoEditorial
MDPI
Materia
Meconium Perfluoroalkyl substances Parabens
Fecha
2024-01-15Referencia bibliográfica
Domínguez-Liste, A.; de Haro-Romero, T.; Quesada-Jiménez, R.; Pérez-Cantero, A.; Peinado, F.M.; Ballesteros, Ó.; Vela-Soria, F. Multiclass Determination of Endocrine-Disrupting Chemicals in Meconium: First Evidence of Perfluoroalkyl Substances in This Biological Compartment. Toxics 2024, 12, 75. https://doi.org/10.3390/toxics12010075
Patrocinador
Miguel Servet postdoctoral research contract (CP21/00128) from the ISCIII and “Fondo Europeo de Desarrollo Regional” (ISCIII/FEDER)Resumen
Major concerns have been raised about human exposure to endocrine-disrupting chemicals
(EDCs) during pregnancy. Effective methodologies for the assessment of this exposure are needed
to support the implementation of preventive measures and the prediction of negative health effects.
Meconium has proven a valuable non-invasive matrix for evaluating cumulative exposure to xenobiotics
during the last two trimesters of pregnancy. The study objective was to develop a novel
method to determine the presence in meconium of perfluoroalkyl substances (PFASs), bisphenols,
parabens, and benzophenones, EDCs that are widely used in the manufacture of numerous consumer
goods and personal care products, including cosmetics. Ten PFASs, two bisphenols, four parabens,
and four benzophenones were measured in meconium samples prepared by using a combination
of Captiva Enhanced Matrix Removal (EMR) lipid cartridges with salt-assisted liquid–liquid extraction
(SALLE) and dispersive liquid–liquid microextraction (DLLME) before the application of
liquid chromatography–tandem mass spectrometry (LC–MS/MS). Experimental parameters were
optimized by applying different chemometric techniques. Limits of detection ranged from 0.05 to
0.1 ng g−1, and between-day variabilities (relative standard deviations) ranged from 6.5% to 14.5%.
The method was validated by matrix-matched standard calibration followed by a recovery assay with
spiked samples, obtaining percentage recoveries of 89.9% to 114.8%. The method was then employed
to measure compounds not previously studied in this matrix in 20 meconium samples. The proposed
analytical procedure yields information on cumulative in utero exposure to selected EDCs.