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dc.contributor.authorDomínguez Liste, Aritz
dc.contributor.authorDe Haro Romero, Teresa
dc.contributor.authorQuesada Jiménez, Raquel
dc.contributor.authorPérez Cantero, Ainhoa
dc.contributor.authorPeinado, Francisco Manuel
dc.contributor.authorBallesteros García, Óscar 
dc.contributor.authorVela Soria, Fernando 
dc.date.accessioned2024-05-10T10:37:04Z
dc.date.available2024-05-10T10:37:04Z
dc.date.issued2024-01-15
dc.identifier.citationDomínguez-Liste, A.; de Haro-Romero, T.; Quesada-Jiménez, R.; Pérez-Cantero, A.; Peinado, F.M.; Ballesteros, Ó.; Vela-Soria, F. Multiclass Determination of Endocrine-Disrupting Chemicals in Meconium: First Evidence of Perfluoroalkyl Substances in This Biological Compartment. Toxics 2024, 12, 75. https://doi.org/10.3390/toxics12010075es_ES
dc.identifier.urihttps://hdl.handle.net/10481/91642
dc.description.abstractMajor concerns have been raised about human exposure to endocrine-disrupting chemicals (EDCs) during pregnancy. Effective methodologies for the assessment of this exposure are needed to support the implementation of preventive measures and the prediction of negative health effects. Meconium has proven a valuable non-invasive matrix for evaluating cumulative exposure to xenobiotics during the last two trimesters of pregnancy. The study objective was to develop a novel method to determine the presence in meconium of perfluoroalkyl substances (PFASs), bisphenols, parabens, and benzophenones, EDCs that are widely used in the manufacture of numerous consumer goods and personal care products, including cosmetics. Ten PFASs, two bisphenols, four parabens, and four benzophenones were measured in meconium samples prepared by using a combination of Captiva Enhanced Matrix Removal (EMR) lipid cartridges with salt-assisted liquid–liquid extraction (SALLE) and dispersive liquid–liquid microextraction (DLLME) before the application of liquid chromatography–tandem mass spectrometry (LC–MS/MS). Experimental parameters were optimized by applying different chemometric techniques. Limits of detection ranged from 0.05 to 0.1 ng g−1, and between-day variabilities (relative standard deviations) ranged from 6.5% to 14.5%. The method was validated by matrix-matched standard calibration followed by a recovery assay with spiked samples, obtaining percentage recoveries of 89.9% to 114.8%. The method was then employed to measure compounds not previously studied in this matrix in 20 meconium samples. The proposed analytical procedure yields information on cumulative in utero exposure to selected EDCs.es_ES
dc.description.sponsorshipMiguel Servet postdoctoral research contract (CP21/00128) from the ISCIII and “Fondo Europeo de Desarrollo Regional” (ISCIII/FEDER)es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMeconiumes_ES
dc.subjectPerfluoroalkyl substanceses_ES
dc.subjectParabenses_ES
dc.titleMulticlass Determination of Endocrine-Disrupting Chemicals in Meconium: First Evidence of Perfluoroalkyl Substances in This Biological Compartmentes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/toxics12010075
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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