Protease inhibitor monotherapy is effective in controlling human immunodeficiency virus 1 shedding in the male genital tract
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Torres-Cornejo, A; BenMarzouk-Hidalgo, OJ; Viciana, P; Sánchez, B; López Ruz, Miguel Ángel; López Cortes, LF; Gutiérrez Valencia, AEditorial
Elsevier
Materia
Human immunodeficiency virus 1 infection Human immunodeficiency virus 1 treatment Male genital tract Protease inhibitor monotherapy Triple therapy
Date
2015-10-08Referencia bibliográfica
Torres-Cornejo et al. Protease inhibitor monotherapy is effective in controlling human immunodeficiency virus 1 shedding in the male genital tract. Clin Microbiol Infect . 2016 Jan;22(1):98.e7-98.e10. https://doi.org/10.1016/j.cmi.2015.09.028
Sponsorship
Junta de Andalucía PI-0168-2012Abstract
Cross-sectional study comparing seminal human immunodeficiency virus type 1 (HIV-1) shedding in patients receiving boosted protease inhibitor monotherapy (mtPI/rtv) (n = 66) versus triple therapy (TT) (n = 61). Seminal HIV-1 shedding rates in patients with undetectable plasma HIV-RNA were 16.0% on mtPI/rtv compared with 28.6% on TT (p 0.173). Aviraemic status and time on viral suppression were independently associated with lack of seminal HIV-1 shedding. During TT, non PI/rtv-based regimens were associated with a better control of HIV infection in semen despite similar time on viral suppression. The use of mtPI/rtv in well-controlled patients is not associated with increased seminal HIV excretion compared with TT.