Microbiological Diagnosis of Infection by the Epstein-Barr Virus: Pathogenic Basis
Identificadores
URI: https://hdl.handle.net/10481/90841Metadata
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Gutiérrez Fernández, José; Solorzano Puerto, Antonio; Soto Pino, María José; Maroto Vela, CarmenEditorial
New developments in Epstein-Barr virus research. Nova Science Publishers, New York
Date
2006-01Referencia bibliográfica
Microbiological diagnosis of infection by the Epstein-Barr virus: pathogenic basis. En: New developments in Epstein-Barr virus research. Nova Science Publishers, (2006)New York
Abstract
This study is a review of current knowledge concerning the pathogeny of infection by the
Epstein-Barr virus. An analysis is made of the biological events that take place in primary
infection, persistent chronic infection, oncogenic transformation, and viral co-infections.
Phenomena surrounding the non-specific clonal stimulation of B lymphocytes are
explained. A review is also made of clinical laboratory tests available for the
serodiagnosis of primary and persistent chronic infections, including the clinical
significance of different classes of antibody, the value of IgG avidity assays and the use of
recombinant antigens in diagnostic equipment. The characteristics of commercially
available equipment are also reported. Laboratory procedures based on previous protocols
are proposed. Finally, the tests that can be used to detect virus-related tumors are
discussed.