Microbiological Diagnosis of Infection by the Epstein-Barr Virus: Pathogenic Basis Gutiérrez Fernández, José Solorzano Puerto, Antonio Soto Pino, María José Maroto Vela, Carmen This study is a review of current knowledge concerning the pathogeny of infection by the Epstein-Barr virus. An analysis is made of the biological events that take place in primary infection, persistent chronic infection, oncogenic transformation, and viral co-infections. Phenomena surrounding the non-specific clonal stimulation of B lymphocytes are explained. A review is also made of clinical laboratory tests available for the serodiagnosis of primary and persistent chronic infections, including the clinical significance of different classes of antibody, the value of IgG avidity assays and the use of recombinant antigens in diagnostic equipment. The characteristics of commercially available equipment are also reported. Laboratory procedures based on previous protocols are proposed. Finally, the tests that can be used to detect virus-related tumors are discussed. 2024-04-17T11:48:57Z 2024-04-17T11:48:57Z 2006-01 info:eu-repo/semantics/bookPart Microbiological diagnosis of infection by the Epstein-Barr virus: pathogenic basis. En: New developments in Epstein-Barr virus research. Nova Science Publishers, (2006)New York https://hdl.handle.net/10481/90841 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional New developments in Epstein-Barr virus research. Nova Science Publishers, New York