Behaviour of IgG antibody avidity for the antigen and of IgA antibody in active cytomegalovirus, Epstein-Barr virus, herpes simplex virus and human herpes virus 6 infections. Adaptation of a commercial test
Metadatos
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Gutiérrez Fernández, José; Rodríguez, M.; Maroto Vela, María del Carmen; Piédrola Angulo, Gonzalo; Peirón, J.Editorial
Elsevier
Fecha
1997-07Referencia bibliográfica
Gutiérrez J, Rodríguez M, Maroto MC, Piédrola G, Peirón J. Behaviour of IgG antibody avidity for the antigen and of IgA antibody in active cytomegalovirus, Epstein-Barr virus, herpes simplex virus and human herpes virus 6 infections. Adaptation of a commercial test. J Infect. 1997 Jul;35(1):25-30. https://doi.org/10.1016/S0163-4453(97)90881-1
Resumen
The clinical value of specific IgA and IgG antibody avidity to herpes simplex virus, cytomegalovirus, Epstein-Barr virus and human herpes virus 6 for the detection of active disease and primary infection, respectively, was evaluated. The IgG avidity test, with a break point of 55%, for the detection of primary infection, and of the IgA test for the detection of disease, were associated with a sensitivity of 97% and 64%, respectively; specificity of 100% and 82%; a positive predictive value of 100% and 76%; and a negative predictive value of 96% and 72%, respectively.