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Hydroxytyrosol influences exercise-induced mitochondrial respiratory complex assembly into supercomplexes in rats
dc.contributor.author | Casuso, Rafael A. | |
dc.contributor.author | Al Fazazi, Saad | |
dc.contributor.author | Hidalgo Gutiérrez, Agustín | |
dc.contributor.author | López García, Luis Carlos | |
dc.contributor.author | Plaza Díaz, Julio | |
dc.contributor.author | Rueda Robles, Ascensión | |
dc.contributor.author | Rodríguez Huertas, Jesús Francisco | |
dc.date.accessioned | 2024-02-09T13:21:46Z | |
dc.date.available | 2024-02-09T13:21:46Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | https://hdl.handle.net/10481/88894 | |
dc.description.abstract | Hydroxytyrosol (HT) has been demonstrated to improve mitochondrial function, both in sedentary and in exercised animals. Herein, we assessed the effects of two different doses of HT on exercise-induced mitochondrial respiratory complex (C) assembly into supercomplexes (SCs) and the relation of the potential results to OPA1 levels and oxidative stress. Wistar rats were allocated into six groups: sedentary (SED), sedentary consuming 20 mg/kg/d of HT (SED-20), sedentary consuming 300 mg/kg/d of HT (SED-300); exercised (EXE), exercised consuming 20 mg/kg/d of HT (EXE-20) and exercised consuming 300 mg/kg/d of HT (EXE-300). Animals were exercised and/or supplemented for 10 weeks, and assembly of SCs, mitochondrial oxidative status and expression of OPA1 were quantified in the gastrocnemius muscle. Both EXE and EXE-20 animals exhibited increased assembly of CI into SCs, but this effect was absent in EXE-300 animals. Levels of CIII2 assembled into SCs were only increased in EXE-20 animals. Notably EXE-300 animals showed a decreased relative expression of s- OPA1 isoforms. Therefore, HT exerted dose-dependent effects on SC assembly in exercised animals. Although the mechanisms leading to SCs assembly in response to exercise and HT are unclear, it seems that a high HT dose can prevent SCs assembly during exercise by decreasing the expression of the s-OPA1 isoforms. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | es_ES |
dc.title | Hydroxytyrosol influences exercise-induced mitochondrial respiratory complex assembly into supercomplexes in rats | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | es_ES |
dc.identifier.doi | 10.1016/j.freeradbiomed.2019.01.027 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |