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Physical exercise improves memory in sedentary middle-aged adults: Are these exercise-induced benefits associated with S-Klotho and 1,25-dihydroxivitamin D? The FIT-AGEING randomized controlled trial
dc.contributor.author | Vázquez Lorente, Héctor | |
dc.contributor.author | De-la-O, Alejandro | |
dc.contributor.author | Amaro Gahete, Francisco José | |
dc.date.accessioned | 2023-11-13T09:33:11Z | |
dc.date.available | 2023-11-13T09:33:11Z | |
dc.date.issued | 2023-10-12 | |
dc.identifier.citation | Vázquez‐Lorente, H., De‐la‐O, A., Carneiro‐Barrera, A., Molina‐Hidalgo, C., Castillo, M. J., & Amaro‐Gahete, F. J. (2023). Physical exercise improves memory in sedentary middle‐aged adults: Are these exercise‐induced benefits associated with S‐Klotho and 1, 25‐dihydroxivitamin D? The FIT‐AGEING randomized controlled trial. Scandinavian Journal of Medicine & Science in Sports.[DOI: 10.1111/sms.14519] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/85611 | |
dc.description.abstract | We aimed to investigate the effect of three types of exercise interventions on memory (i.e., immediate memory (IM), long-term memory (LTM), and recognition). We also investigated whether exercise-induced changes in circulating S-Klotho and 1,25-dihydroxivitamin D (1,25(OH)2D) levels were related to those observed in memory in healthy middle-aged sedentary adults. A 12-week randomized controlled trial was performed with a parallel-group design. Seventy-four participants (45–65 years old: 53% women) were randomly assigned to (1) no exercise (control) group, (2) concurrent training based on the international physical activity recommendations (PAR) group, (3) high-intensity interval training (HIIT) group, or (4) HIIT plus whole-body electromyostimulation (HIIT-EMS) group. Memory outcomes were assessed using the Wechsler Memory Scale-third edition. S-Klotho plasma levels were determined according to a solid-phase sandwich enzyme-linked immunosorbent assay kit while 1,25(OH)2D plasma levels were measured using a DiaSorin-Liaison immunochemiluminometric analyzer. IM-Verbal Paired Associates (IM-VPA) and IM-Logical Memory (IM-LM) were improved in both the HIIT and HIIT-EMS groups compared with the control group (all p ≤ 0.045). Exercise-induced changes in S-Klotho plasma levels were positively associated with those observed in IM, LTM, and recognition (all p ≤ 0.007), whereas exercise-induced changes in 1,25(OH)2D plasma levels were directly related to changes in IM and LTM (all p ≤ 0.048). In conclusion, a 12-week HIIT intervention with or without WB-EMS seems to be the most effective exercise program to improve IM. The significant and positive associations between exercise-induced changes in S-Klotho and 1,25(OH)2D levels with those observed in memory outcomes suggest that these factors may be potentially related to exercise-induced improvements of memory in middle-aged adults. | es_ES |
dc.description.sponsorship | FEDER/Junta de Andalucía-Consejería de Economía y Conocimiento/Proyecto B462, | es_ES |
dc.description.sponsorship | Grant/Award Number: CTS-363- UGR18 | es_ES |
dc.description.sponsorship | Spanish Ministry of Education | es_ES |
dc.description.sponsorship | Grant/Award Number: FPU18/03655 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | 1,25-dihydroxivitamin D | es_ES |
dc.subject | Long-term memory | es_ES |
dc.subject | Physical exercise | es_ES |
dc.subject | Short-term memory | es_ES |
dc.subject | S-Klotho | es_ES |
dc.title | Physical exercise improves memory in sedentary middle-aged adults: Are these exercise-induced benefits associated with S-Klotho and 1,25-dihydroxivitamin D? The FIT-AGEING randomized controlled trial | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1111/sms.14519 | |
dc.type.hasVersion | VoR | es_ES |