Physical exercise improves memory in sedentary middle-aged adults: Are these exercise-induced benefits associated with S-Klotho and 1,25-dihydroxivitamin D? The FIT-AGEING randomized controlled trial
Metadatos
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Wiley
Materia
1,25-dihydroxivitamin D Long-term memory Physical exercise Short-term memory S-Klotho
Fecha
2023-10-12Referencia bibliográfica
Vázquez‐Lorente, H., De‐la‐O, A., Carneiro‐Barrera, A., Molina‐Hidalgo, C., Castillo, M. J., & Amaro‐Gahete, F. J. (2023). Physical exercise improves memory in sedentary middle‐aged adults: Are these exercise‐induced benefits associated with S‐Klotho and 1, 25‐dihydroxivitamin D? The FIT‐AGEING randomized controlled trial. Scandinavian Journal of Medicine & Science in Sports.[DOI: 10.1111/sms.14519]
Patrocinador
FEDER/Junta de Andalucía-Consejería de Economía y Conocimiento/Proyecto B462,; Grant/Award Number: CTS-363- UGR18; Spanish Ministry of Education; Grant/Award Number: FPU18/03655Resumen
We aimed to investigate the effect of three types of exercise interventions
on memory (i.e., immediate memory (IM), long-term
memory (LTM), and
recognition). We also investigated whether exercise-induced
changes in circulating
S-Klotho
and 1,25-dihydroxivitamin
D (1,25(OH)2D) levels were related to
those observed in memory in healthy middle-aged
sedentary adults. A 12-week
randomized controlled trial was performed with a parallel-group
design. Seventy-four
participants (45–65
years old: 53% women) were randomly assigned to (1)
no exercise (control) group, (2) concurrent training based on the international
physical activity recommendations (PAR) group, (3) high-intensity
interval
training (HIIT) group, or (4) HIIT plus whole-body
electromyostimulation (HIIT-EMS)
group. Memory outcomes were assessed using the Wechsler Memory Scale-third
edition. S-Klotho
plasma levels were determined according to a solid-phase
sandwich enzyme-linked
immunosorbent assay kit while 1,25(OH)2D plasma
levels were measured using a DiaSorin-Liaison
immunochemiluminometric
analyzer. IM-Verbal
Paired Associates (IM-VPA)
and IM-Logical
Memory (IM-LM)
were improved in both the HIIT and HIIT-EMS
groups compared with the
control group (all p ≤ 0.045). Exercise-induced
changes in S-Klotho
plasma levels
were positively associated with those observed in IM, LTM, and recognition (all
p ≤ 0.007), whereas exercise-induced
changes in 1,25(OH)2D plasma levels were
directly related to changes in IM and LTM (all p ≤ 0.048). In conclusion, a 12-week
HIIT intervention with or without WB-EMS
seems to be the most effective
exercise program to improve IM. The significant and positive associations between
exercise-induced
changes in S-Klotho
and 1,25(OH)2D levels with those observed
in memory outcomes suggest that these factors may be potentially related to
exercise-induced
improvements of memory in middle-aged
adults.