The NLRP3 inflammasome: contributions to inflammation‑related diseases

Chen, Ying; Escames Rosa, Germaine

s11658-023-00462-9.pdf (1.717Mb)

Identificadores

URI: https://hdl.handle.net/10481/84855

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Editorial

Springer Nature

Materia

NLRP3 inflammasome

Innate immunity

Inflammatory disease

Fecha

2023-06-27

Referencia bibliográfica

Chen, Y., Ye, X., Escames, G. et al. The NLRP3 inflammasome: contributions to inflammation-related diseases. Cell Mol Biol Lett 28, 51 (2023). [https://doi.org/10.1186/s11658-023-00462-9]

Patrocinador

National Natural Science Foundation of China, 82200330, 82070422, 81871607; Youth Science and Technology Rising Star Project of Shaanxi Province; 2020KJXX-036, Innovation Capability Strong Foundation Plan of Xi’an City, 21YXYJ0037

Resumen

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including arthritis, Alzheimer’s disease, inflammatory bowel disease, and other autoimmune and autoinflammatory diseases. This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the NLRP3 inflammasome to treat inflammation-related diseases, and provide new ideas for clinical treatment.

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DFisiología - Artículos

Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución 4.0 Internacional