@misc{10481/84855,
year = {2023},
month = {6},
url = {https://hdl.handle.net/10481/84855},
abstract = {The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including arthritis, Alzheimer’s disease, inflammatory bowel disease, and other autoimmune and autoinflammatory diseases. This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the NLRP3 inflammasome to treat inflammation-related diseases, and provide new ideas for clinical treatment.},
organization = {National Natural Science Foundation of China, 82200330, 82070422, 81871607},
organization = {Youth Science and Technology Rising Star
Project of Shaanxi Province},
organization = {2020KJXX-036, Innovation Capability Strong Foundation Plan of Xi’an City, 21YXYJ0037},
publisher = {Springer Nature},
keywords = {NLRP3 inflammasome},
keywords = {Innate immunity},
keywords = {Inflammatory disease},
title = {The NLRP3 inflammasome: contributions to inflammation‑related diseases},
author = {Chen, Ying and Escames Rosa, Germaine},
}