Toward the use of mixed microbial cultures for the biological production of adipic and levulinic acid
Metadatos
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Frontiers Media
Materia
Adipic acid Levulinic acid Mixed microbial cultures (MMC) Hemicellulose hydrolysate Feast Famine
Fecha
2023-06-28Referencia bibliográfica
Pinto-Ibieta F, Cea M, Serrano A, Felissia FE, Area MC, Cabrera F and Ciudad G (2023). Toward the use of mixed microbial cultures for the biological production of adipic and levulinic acid. Front. Microbiol. 14:1224543. [doi: 10.3389/fmicb.2023.1224543]
Patrocinador
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 3210626; Agencia Nacional de Investigacion y Desarrollo de Chile, ANID; Universities Department of the Andalucia Autonomous Government for his Emergia fellowship (EMERGIA20_00114)Resumen
Biological synthesis of high added-value compounds like adipic acid (AA), levulinic acid (LA), or polyhydroxybutyrate (PHB) using pure culture has been separately reported. However, pure culture requires sterile conditions and the use of specific carbon sources resulting in high operating costs. Different alternatives based on the use of mixed microbial cultures (MMC) have been explored to resolve this problem. MMC have been widely reported for the production of PHB, but scarcely reported for LA production and never for AA synthesis. This work presents a novel strategy for the co-production of AA LA, and PHB using MMC. The strategy consists in selecting an MMC producer of AA, LA and PHB from an inoculum obtained from a wastewater treatment plant, which is then subjected to the feast and famine culture strategy in a sequential batch reactor, coupled with a batch reactor step to enhance the accumulation of AA and LA. The results showed that the MMC could produce a 16 & PLUSMN; 2, 23 & PLUSMN; 1 and 5 & PLUSMN; %1 (g compound/g volatile solids) of AA, LA and PHB, respectively, using a non-fermented residual biomass rich in pentose, namely synthetic hemicellulose hydrolysate (SHH) as the carbon source. These results contribute to generating future research to better understand and optimise the biosynthesis of these compounds by MMC.