Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models
MetadataShow full item record
AuthorVarela López, Alfonso; Romero Márquez, José Manuel; Navarro Hortal, María D.; Ramírez Tortosa, César Luis; Forbes Hernández, Tamara Yuliett; Quiles Morales, José Luis
AgingAgeingLongevityBioactive compoundsNutrient-sensing pathwaysHormesis
A. Varela-López et al. Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models. Experimental Gerontology 178 (2023) 112221 2 [https://doi.org/10.1016/j.exger.2023.112221]
SponsorshipGrant reference FPU2017/04358; FPU2018/05301; MCIN/AEI/10.13039/501100011033; Grant reference IJC2020-043910-I; NextGenerationEU; Grant PID2019-106778RB-I00; MCIN/AEI/10.13039/ 501100011033 FEDER “Una manera de hacer Europa
The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of all age-associated chronic disorders can be delayed because these pathologies share age as primary underlying risk factor. One of the most extended ideas is that aging is consequence of the accumulation of molecular damage. According to the oxidative damage theory, antioxidants should slow down aging, extending lifespan and healthspan. The present review analyzes studies evaluating the effect of dietary antioxidants on lifespan of different aging models and discusses the evidence on favor of their antioxidant activity as anti-aging mechanisms. Moreover, possible causes for differences between the reported results are evaluated.