Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models Varela López, Alfonso Romero Márquez, José Manuel Navarro Hortal, María D. Ramírez Tortosa, César Luis Forbes Hernández, Tamara Yuliett Quiles Morales, José Luis Aging Ageing Longevity Bioactive compounds Nutrient-sensing pathways Hormesis The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of all age-associated chronic disorders can be delayed because these pathologies share age as primary underlying risk factor. One of the most extended ideas is that aging is consequence of the accumulation of molecular damage. According to the oxidative damage theory, antioxidants should slow down aging, extending lifespan and healthspan. The present review analyzes studies evaluating the effect of dietary antioxidants on lifespan of different aging models and discusses the evidence on favor of their antioxidant activity as anti-aging mechanisms. Moreover, possible causes for differences between the reported results are evaluated. 2023-07-25T11:23:19Z 2023-07-25T11:23:19Z 2023-05-31 journal article A. Varela-López et al. Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models. Experimental Gerontology 178 (2023) 112221 2 [https://doi.org/10.1016/j.exger.2023.112221] https://hdl.handle.net/10481/83979 10.1016/j.exger.2023.112221 eng info:eu-repo/grantAgreement/EC/NextGenerationEU/IJC2020-043910-I http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier