Genetic markers associated with bone composition in Rhode Island Red laying hens
Metadatos
Afficher la notice complèteAuteur
Sallam, Moh; Benavides Reyes, Cristina; Domínguez Gasca, Nazaret; Sánchez Rodríguez, Estefanía; Rodríguez Navarro, AlejandroEditorial
Springer Nature
Date
2023-06-29Referencia bibliográfica
Sallam, M., Wilson, P.W., Andersson, B. et al. Genetic markers associated with bone composition in Rhode Island Red laying hens. Genet Sel Evol 55, 44 (2023). [https://doi.org/10.1186/s12711-023-00818-x]
Patrocinador
Swedish University of Agricultural Sciences.; ERANET Grant to ICD (BBSRC BB/ M028291/1); Svenska Forskningsrådet Formas, 2014-01840; (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, 291815; Svenska Forskningsrådet Formas (2019-02116 and 2016-01386); The COST Action CA15224 Keel Bone DamageRésumé
Background Bone damage has welfare and economic impacts on modern commercial poultry and is known as one
of the major challenges in the poultry industry. Bone damage is particularly common in laying hens and is probably
due to the physiological link between bone and the egg laying process. Previous studies identified and validated
quantitative trait loci (QTL) for bone strength in White Leghorn laying hens based on several measurements, including
bone composition measurements on the cortex and medulla of the tibia bone. In a previous pedigree-based analysis,
bone composition measurements showed heritabilities ranging from 0.18 to 0.41 and moderate to strong genetic
correlations with tibia strength and density. Bone composition was measured using infrared spectroscopy and
thermogravimetry. The aim of this study was to combine these bone composition measurements with genotyping
data via a genome-wide association study (GWAS) to investigate genetic markers that contribute to genetic variance
in bone composition in Rhode Island Red laying hens. In addition, we investigated the genetic correlations between
bone composition and bone strength.
Results We found novel genetic markers that are significantly associated with cortical lipid, cortical mineral scattering,
medullary organic matter, and medullary mineralization. Composition of the bone organic matter showed
more significant associations than bone mineral composition. We also found interesting overlaps between the GWAS
results for tibia composition traits, particularly for cortical lipid and tibia strength. Bone composition measurements
by infrared spectroscopy showed more significant associations than thermogravimetry measurements. Based on the
results of infrared spectroscopy, cortical lipid showed the highest genetic correlations with tibia density, which was
negative (− 0.20 ± 0.04), followed by cortical CO3/PO4 (0.18 ± 0.04). Based on the results of thermogravimetry, medullary
organic matter% and mineral% showed the highest genetic correlations with tibia density (− 0.25 ± 0.04 and
0.25 ± 0.04, respectively).
Conclusions This study detected novel genetic associations for bone composition traits, particularly those involving
organic matter, that could be used as a basis for further molecular genetic investigations. Tibia cortical lipids displayed
the strongest genetic associations of all the composition measurements, including a significantly high genetic correlation
with tibia density and strength. Our results also highlighted that cortical lipid may be a key measurement for
further avian bone studies.