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dc.contributor.authorSallam, Moh
dc.contributor.authorBenavides Reyes, Cristina 
dc.contributor.authorDomínguez Gasca, Nazaret
dc.contributor.authorSánchez Rodríguez, Estefanía
dc.contributor.authorRodríguez Navarro, Alejandro 
dc.date.accessioned2023-07-25T07:58:41Z
dc.date.available2023-07-25T07:58:41Z
dc.date.issued2023-06-29
dc.identifier.citationSallam, M., Wilson, P.W., Andersson, B. et al. Genetic markers associated with bone composition in Rhode Island Red laying hens. Genet Sel Evol 55, 44 (2023). [https://doi.org/10.1186/s12711-023-00818-x]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/83960
dc.description.abstractBackground Bone damage has welfare and economic impacts on modern commercial poultry and is known as one of the major challenges in the poultry industry. Bone damage is particularly common in laying hens and is probably due to the physiological link between bone and the egg laying process. Previous studies identified and validated quantitative trait loci (QTL) for bone strength in White Leghorn laying hens based on several measurements, including bone composition measurements on the cortex and medulla of the tibia bone. In a previous pedigree-based analysis, bone composition measurements showed heritabilities ranging from 0.18 to 0.41 and moderate to strong genetic correlations with tibia strength and density. Bone composition was measured using infrared spectroscopy and thermogravimetry. The aim of this study was to combine these bone composition measurements with genotyping data via a genome-wide association study (GWAS) to investigate genetic markers that contribute to genetic variance in bone composition in Rhode Island Red laying hens. In addition, we investigated the genetic correlations between bone composition and bone strength. Results We found novel genetic markers that are significantly associated with cortical lipid, cortical mineral scattering, medullary organic matter, and medullary mineralization. Composition of the bone organic matter showed more significant associations than bone mineral composition. We also found interesting overlaps between the GWAS results for tibia composition traits, particularly for cortical lipid and tibia strength. Bone composition measurements by infrared spectroscopy showed more significant associations than thermogravimetry measurements. Based on the results of infrared spectroscopy, cortical lipid showed the highest genetic correlations with tibia density, which was negative (− 0.20 ± 0.04), followed by cortical CO3/PO4 (0.18 ± 0.04). Based on the results of thermogravimetry, medullary organic matter% and mineral% showed the highest genetic correlations with tibia density (− 0.25 ± 0.04 and 0.25 ± 0.04, respectively). Conclusions This study detected novel genetic associations for bone composition traits, particularly those involving organic matter, that could be used as a basis for further molecular genetic investigations. Tibia cortical lipids displayed the strongest genetic associations of all the composition measurements, including a significantly high genetic correlation with tibia density and strength. Our results also highlighted that cortical lipid may be a key measurement for further avian bone studies.es_ES
dc.description.sponsorshipSwedish University of Agricultural Sciences.es_ES
dc.description.sponsorshipERANET Grant to ICD (BBSRC BB/ M028291/1)es_ES
dc.description.sponsorshipSvenska Forskningsrådet Formas, 2014-01840es_ES
dc.description.sponsorship(Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, 291815es_ES
dc.description.sponsorshipSvenska Forskningsrådet Formas (2019-02116 and 2016-01386)es_ES
dc.description.sponsorshipThe COST Action CA15224 Keel Bone Damagees_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleGenetic markers associated with bone composition in Rhode Island Red laying henses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1186/s12711-023-00818-x
dc.type.hasVersionVoRes_ES


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