Antioxidant Efficacy and “In Vivo” Safety of a Bentonite/Vitamin C Hybrid
Metadata
Show full item recordAuthor
Hernández Oliva, Dayaris; Sánchez Espejo, Rita María; Cerezo González, María Pilar; Viseras Iborra, César Antonio; César Antonio, Viseras Iborra,Editorial
MDPI
Materia
Bentonite L-ascorbic acid Antioxidant capacity Photoprotection
Date
2023-04-07Referencia bibliográfica
Hernández, D.; Montalvo, A.; Pérez, I.; Charnay, C.; Sánchez-Espejo, R.; Cerezo, P.; Viseras, C.; Riela, S.; Cinà, G.; Rivera, A. Antioxidant Efficacy and “In Vivo” Safety of a Bentonite/Vitamin C Hybrid. Pharmaceutics 2023, 15, 1171. [https://doi.org/10.3390/pharmaceutics15041171]
Sponsorship
France Embassy in Cuba; Erasmus+ scholarship; TWAS 00-360 RG/CHE/LA, 07-016 RG/CHE/LA; PN211LH008-027, PN223LH010-017Abstract
L-ascorbic acid (LAA), commonly known as vitamin C, is an excellent and recognized
antioxidant molecule used in pharmaceutical and cosmetic formulations. Several strategies have
been developed in order to preserve its chemical stability, connected with its antioxidant power, but
there is little research regarding the employment of natural clays as LAA host. A safe bentonite
(Bent)—which was verified by in vivo ophthalmic irritability and acute dermal toxicity assays—was
used as carrier of LAA. The supramolecular complex between LAA and clay may constitute an
excellent alternative, since the molecule integrity does not seem to be affected, at least from the point
of view of its antioxidant capacity. The Bent/LAA hybrid was prepared and characterized through
ultraviolet (UV) spectroscopy, X-ray diffraction (XRD), infrared (IR) spectroscopy, thermogravimetric
analysis (TG/DTG) and zeta potential measurements. Photostability and antioxidant capacity tests
were also performed. The LAA incorporation into Bent clay was demonstrated, as well as the drug
stability due to the Bent photoprotective effect onto the LAA molecule. Moreover, the antioxidant
capacity of the drug in the Bent/LAA composite was confirmed.