Click to learn, learn to click: undergraduate synthetic organic chemistry experiments
Identificadores
URI: https://hdl.handle.net/10481/81742Metadatos
Mostrar el registro completo del ítemAutor
Lopez-Ruiz, Alejandro; Ortega-Muñoz, Mariano; Santoyo-Gonzalez, Francisco; Megia-Fernandez, AliciaMateria
Click chemistry Cycloaddition
Fecha
2023-05-11Patrocinador
FQM-208. GlycoChemBio: Glycochemistry and BioconjugationResumen
The optimization of an undergraduate experiment for Organic Chemistry students is described to explore the concept of
click chemistry. The preparation of a terminal fluorescent alkyne and an organic azide is reported consisting of simple steps.
These are employed in the Cu(I)-catalized azide-alkyne cycloaddition to obtain a novel molecule containing a triazole ring
whose characterization allows the students to practice a variety of techniques: NMR (1H, 13C, COSY and HSQC), melting
point, thin layer chromatography, IR, fluorescence spectroscopy and mass spectrometry to confirm the structure of their
obtained product. An alternative methodology in a one-pot reaction is also explored and a full laboratory manual provided.