@misc{10481/81742,
year = {2023},
month = {5},
url = {https://hdl.handle.net/10481/81742},
abstract = {The optimization of an undergraduate experiment for Organic Chemistry students is described to explore the concept of
click chemistry. The preparation of a terminal fluorescent alkyne and an organic azide is reported consisting of simple steps.
These are employed in the Cu(I)-catalized azide-alkyne cycloaddition to obtain a novel molecule containing a triazole ring
whose characterization allows the students to practice a variety of techniques: NMR (1H, 13C, COSY and HSQC), melting
point, thin layer chromatography, IR, fluorescence spectroscopy and mass spectrometry to confirm the structure of their
obtained product. An alternative methodology in a one-pot reaction is also explored and a full laboratory manual provided.},
organization = {FQM-208. GlycoChemBio: Glycochemistry and Bioconjugation},
keywords = {Click chemistry},
keywords = {Cycloaddition},
title = {Click to learn, learn to click: undergraduate synthetic organic chemistry experiments},
doi = {https://doi.org/10.1007/s11696-023-02858-5},
author = {Lopez-Ruiz, Alejandro and Ortega-Muñoz, Mariano and Santoyo-Gonzalez, Francisco and Megia-Fernandez, Alicia},
}