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dc.contributor.authorRomero Márquez, José Manuel 
dc.contributor.authorForbes Hernández, Tamara Yuliett 
dc.contributor.authorNavarro Hortal, María Dolores 
dc.contributor.authorSánchez González, Cristina 
dc.contributor.authorQuiles Morales, José Luis 
dc.date.accessioned2023-05-04T08:37:27Z
dc.date.available2023-05-04T08:37:27Z
dc.date.issued2023-02-22
dc.identifier.citationRomero-Márquez, J.M.; Forbes-Hernández, T.Y.; Navarro-Hortal, M.D.; Quirantes-Piné, R.; Grosso, G.; Giampieri, F.; Lipari, V.; Sánchez-González, C.; Battino, M.; Quiles, J.L. Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s Disease. Int. J. Mol. Sci. 2023, 24, 4353. [https://doi.org/10.3390/ijms24054353]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/81324
dc.description.abstractAlzheimer’s Disease (AD) is the cause of around 60–70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees (Olea europaea) are the most abundant by-products of the olive grove industry. These by-products have been highlighted due to the wide variety of bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-β formation but also neurofibrillary tangles formation through amyloid protein precursor processing modulation. Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying these protective effects may be associated with decreased neuroinflammation and oxidative stress via NF-κB and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as an adjuvant in the treatment of ADes_ES
dc.description.sponsorshipGrants PID2019-106778RB-I00, funded by MCIN/AEI/10.13039/501100011033 FEDER “Una manera de hacer Europa”,es_ES
dc.description.sponsorshipSUSTAINOLIVE (PRIMA H2020-1811).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectOlive leaveses_ES
dc.subjectBioactive compoundses_ES
dc.subjectAlzheimer’s diseasees_ES
dc.subjectHydroxytyrosoles_ES
dc.titleMolecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s Diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/ijms24054353
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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