Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s Disease
Metadatos
Afficher la notice complèteAuteur
Romero Márquez, José Manuel; Forbes Hernández, Tamara Yuliett; Navarro Hortal, María Dolores; Sánchez González, Cristina; Quiles Morales, José LuisEditorial
MDPI
Materia
Olive leaves Bioactive compounds Alzheimer’s disease Hydroxytyrosol
Date
2023-02-22Referencia bibliográfica
Romero-Márquez, J.M.; Forbes-Hernández, T.Y.; Navarro-Hortal, M.D.; Quirantes-Piné, R.; Grosso, G.; Giampieri, F.; Lipari, V.; Sánchez-González, C.; Battino, M.; Quiles, J.L. Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s Disease. Int. J. Mol. Sci. 2023, 24, 4353. [https://doi.org/10.3390/ijms24054353]
Patrocinador
Grants PID2019-106778RB-I00, funded by MCIN/AEI/10.13039/501100011033 FEDER “Una manera de hacer Europa”,; SUSTAINOLIVE (PRIMA H2020-1811).Résumé
Alzheimer’s Disease (AD) is the cause of around 60–70% of global cases of dementia
and approximately 50 million people have been reported to suffer this disease worldwide. The
leaves of olive trees (Olea europaea) are the most abundant by-products of the olive grove industry.
These by-products have been highlighted due to the wide variety of bioactive compounds such
as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight
AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-β formation but
also neurofibrillary tangles formation through amyloid protein precursor processing modulation.
Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL
demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying
these protective effects may be associated with decreased neuroinflammation and oxidative stress
via NF-κB and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that
OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower
toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as
an adjuvant in the treatment of AD