Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis
Metadatos
Mostrar el registro completo del ítemEditorial
MDPI
Materia
Differentiation Epigenetics LIN28 NANOG POU5F1 SOX2 Testis cancer
Fecha
2023-02-19Referencia bibliográfica
von Eyben, F.E.; Kristiansen, K.; Kapp, D.S.; Hu, R.; Preda, O.; Nogales, F.F. Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis. Int. J. Mol. Sci. 2023, 24, 4148. [https://doi.org/10.3390/ijms24044148]
Patrocinador
Minister Erna Hamiltons Foundation for art and sciencesResumen
In testicular germ cell tumor type II (TGCT), a seminoma subtype expresses an induced
pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/POU5F1, SOX17, KLF4, and
MYC, and embryonal carcinoma (EC) has four upregulated genes, OCT4/POU5F1, SOX2, LIN28, and
NANOG. The EC panel can reprogram cells into iPSC, and both iPSC and EC can differentiate into
teratoma. This review summarizes the literature on epigenetic regulation of the genes. Epigenetic
mechanisms, such as methylations of cytosines on the DNA string and methylations and acetylations
of histone 3 lysines, regulate expression of these driver genes between the TGCT subtypes. In
TGCT, the driver genes contribute to well-known clinical characteristics and the driver genes are also
important for aggressive subtypes of many other malignancies. In conclusion, epigenetic regulation
of the driver genes are important for TGCT and for oncology in general.