Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis von Eyben, Finn E. Preda, Ovidiu Nogales Fernández, Francisco Differentiation Epigenetics LIN28 NANOG POU5F1 SOX2 Testis cancer Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/ijms24044148/s1. In testicular germ cell tumor type II (TGCT), a seminoma subtype expresses an induced pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/POU5F1, SOX17, KLF4, and MYC, and embryonal carcinoma (EC) has four upregulated genes, OCT4/POU5F1, SOX2, LIN28, and NANOG. The EC panel can reprogram cells into iPSC, and both iPSC and EC can differentiate into teratoma. This review summarizes the literature on epigenetic regulation of the genes. Epigenetic mechanisms, such as methylations of cytosines on the DNA string and methylations and acetylations of histone 3 lysines, regulate expression of these driver genes between the TGCT subtypes. In TGCT, the driver genes contribute to well-known clinical characteristics and the driver genes are also important for aggressive subtypes of many other malignancies. In conclusion, epigenetic regulation of the driver genes are important for TGCT and for oncology in general. 2023-04-28T09:07:41Z 2023-04-28T09:07:41Z 2023-02-19 journal article von Eyben, F.E.; Kristiansen, K.; Kapp, D.S.; Hu, R.; Preda, O.; Nogales, F.F. Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis. Int. J. Mol. Sci. 2023, 24, 4148. [https://doi.org/10.3390/ijms24044148] https://hdl.handle.net/10481/81291 10.3390/ijms24044148 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI