Role of Melatonin in Cancer: Effect on Clock Genes
Metadatos
Afficher la notice complèteAuteur
Rodríguez Santana, César; Florido Ruiz, Javier; Martínez Ruiz, Laura; López Rodríguez, Alba; Acuña Castroviejo, Darío; Escames Rosa, GermaineEditorial
MDPI
Materia
Melatonin Cancer Clock genes Circadian rhythms SIRT1 c-Myc
Date
2023-01-18Referencia bibliográfica
Rodríguez-Santana, C... [et al.]. Role of Melatonin in Cancer: Effect on Clock Genes. Int. J. Mol. Sci. 2023, 24, 1919. [https://doi.org/10.3390/ijms24031919]
Patrocinador
MCIN/AEI/10.13039/501100011033; ERDF (SAF2017-85903-P, ID2020-115112RB-I00), from the Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía (P07-CTS-03135, P10-CTS-5784, and CTS-101); FPU fellowships from the Ministerio de Educación Cultura y Deporte, SpainRésumé
The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that
generates rhythmic changes in many physiological processes. Increasing evidence links chronodisruption
with aberrant functionality in clock gene expression, resulting in multiple diseases, including
cancer. In this context, tumor cells have an altered circadian machinery compared to normal cells,
which deregulates the cell cycle, repair mechanisms, energy metabolism and other processes. Melatonin
is the main hormone produced by the pineal gland, whose production and secretion oscillates
in accordance with the light:dark cycle. In addition, melatonin regulates the expression of clock genes,
including those in cancer cells, which could play a key role in the numerous oncostatic effects of
this hormone. This review aims to describe and clarify the role of clock genes in cancer, as well as
the possible mechanisms of the action of melatonin through which it regulates the expression of the
tumor’s circadian machinery, in order to propose future anti-neoplastic clinical treatments.