@misc{10481/80720,
year = {2023},
month = {1},
url = {https://hdl.handle.net/10481/80720},
abstract = {The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that
generates rhythmic changes in many physiological processes. Increasing evidence links chronodisruption
with aberrant functionality in clock gene expression, resulting in multiple diseases, including
cancer. In this context, tumor cells have an altered circadian machinery compared to normal cells,
which deregulates the cell cycle, repair mechanisms, energy metabolism and other processes. Melatonin
is the main hormone produced by the pineal gland, whose production and secretion oscillates
in accordance with the light:dark cycle. In addition, melatonin regulates the expression of clock genes,
including those in cancer cells, which could play a key role in the numerous oncostatic effects of
this hormone. This review aims to describe and clarify the role of clock genes in cancer, as well as
the possible mechanisms of the action of melatonin through which it regulates the expression of the
tumor’s circadian machinery, in order to propose future anti-neoplastic clinical treatments.},
organization = {MCIN/AEI/10.13039/501100011033},
organization = {ERDF (SAF2017-85903-P, ID2020-115112RB-I00), from the Consejería de Innovación, Ciencia
y Empresa, Junta de Andalucía (P07-CTS-03135, P10-CTS-5784, and CTS-101)},
organization = {FPU fellowships from the Ministerio de Educación Cultura y Deporte, Spain},
publisher = {MDPI},
keywords = {Melatonin},
keywords = {Cancer},
keywords = {Clock genes},
keywords = {Circadian rhythms},
keywords = {SIRT1},
keywords = {c-Myc},
title = {Role of Melatonin in Cancer: Effect on Clock Genes},
doi = {10.3390/ijms24031919},
author = {Rodríguez Santana, César and Florido Ruiz, Javier and Martínez Ruiz, Laura and López Rodríguez, Alba and Acuña Castroviejo, Darío and Escames Rosa, Germaine},
}