Influence of BPA exposure, measured in saliva, on childhood weight
Metadata
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Heras González, Leticia; Espino, Diana; Jiménez Casquet, María José; López Moro, Alejandro; Olea Serrano, Fátima; Mariscal Arcas, MiguelEditorial
Frontiers
Materia
BPA Saliva Childhood Weight Endocrine disruptors
Date
2022-12-08Referencia bibliográfica
Heras-Gonza´ lez L... [et al.] (2022) Influence of BPA exposure, measured in saliva, on childhood weight. Front. Endocrinol. 13:1040583. doi: [10.3389/fendo.2022.1040583]
Sponsorship
FEDER-ISCIII PI14/01040; Counselling of Economic Transformation, Industry, Knowledge and Universities-Junta de Andalucı́a (P18-RT-4247 and PE- 0250-2019); EFSA Partnering Grants (GP/EFSA/ENCO/2018/ 03); The High Council for Sports (CSD); Spanish Ministry of Culture and Sport (RED RDFD “Functional Sports Dynamometry” Ref. 06/UPB/22)Abstract
Introduction: Endocrine disruptors such as bisphenol A (BPA), BPA glycidyl
methacrylate, and other BPA acrylate–based derivatives have been related to
type 2 diabetes, the metabolic syndrome, and obesity, among other metabolic
disorders. The objective of this study is to examine the influence of BPA exposure
by saliva analysis and daily physical activity on the risk of overweight/obesity in
schoolchildren from southern Spain.
Methods: The study included 300 children (53.5% girls) aged 7–10 years.
Participants completed a questionnaire with four sections: participant data,
including demographic information and life and family habits; semiquantitative
food frequency questionnaire; anthropometric variables; and
physical activity variables. All participants underwent dental examination,
when the presence of sealants/composites in each tooth and other dental
alterations was recorded, and samples of whole saliva were collected for
UHPLC-MS/MS analyses.
Results: Risk of overweight/obesity was significantly influenced by body fat
composition (OR = 10.77), not walking to and from school (OR = 1.38), lesser
energy expenditure in sedentary activities (OR = 12.71), greater energy
expenditure in sports (OR =1.62), and exposure to BPA from dental sealants/
composites (OR = 1.38; p = 0.058).
Discussion: Further research is warranted on this issue in children, who may be
especially vulnerable to the negative health effects of endocrine disruption.