Colon cancer therapy with calcium phosphate nanoparticles loading bioactive compounds from Euphorbia lathyris: In vitro and in vivo assay
Metadatos
Afficher la notice complèteAuteur
Mesas Hernández, Cristina; Garcés Robles, Víctor Jesús; Martínez Martínez, Rosario; Ortiz Quesada, Raúl; Doello González, Kevin; Domínguez Vera, José Manuel; Porres Foulquie, Jesús María; López-Jurado Romero De La Cruz, María; Melguizo Alonso, Consolación; Delgado López, José Manuel; Prados Salazar, José CarlosEditorial
Elsevier
Materia
Calcium phosphate nanoparticles Euphorbia lathyris Colon cancer Esculetin Euphorbetin
Date
2022-09-23Referencia bibliográfica
Cristina Mesas... [et al.]. Colon cancer therapy with calcium phosphate nanoparticles loading bioactive compounds from Euphorbia lathyris: In vitro and in vivo assay, Biomedicine & Pharmacotherapy, Volume 155, 2022, 113723, ISSN 0753-3322, [https://doi.org/10.1016/j.biopha.2022.113723]
Patrocinador
Spanish Government; European Commission PTQ-17-09172 RTC-2017-6540-1 RTI2018-100934-B-I00 RTC2019-006870-1 RYC2016-21042; Junta de Andalucia FEDER program P18-TP-1420 A-CTS666-UGR20 B-CTS-122-UGR20 P18-HO-3882 P18-TP-0969; Andalusian Government AGR145 FQM-368 CTS-107Résumé
Amorphous calcium phosphate nanoparticles (ACP NPs) exhibit excellent biocompatibility and biodegradability
properties. ACP NPs were functionalized with two coumarin compounds (esculetin and euphorbetin) extracted
from Euphorbia lathyris seeds (BC-ACP NPs) showing high loading capacity (0.03% and 0.34% (w/w) for esculetin
and euphorbetin, respectively) and adsorption efficiency (2.6% and 33.5%, respectively). BC-ACP NPs, no toxic
to human blood cells, showed a more selective cytotoxicity against colorectal cancer (CRC) cells (T-84 cells)
(IC50, 71.42 μg/ml) compared to non-tumor (CCD18) cells (IC50, 420.77 μg/ml). Both, the inhibition of carbonic
anhydrase and autophagic cell death appeared to be involved in their action mechanism. Interestingly, in vivo
treatment with BC-ACPs NPs using two different models of CRC induction showed a significant reduction in
tumor volume (62%) and a significant decrease in the number and size of polyps. A poor development of tumor
vasculature and invasion of normal tissue were also observed. Moreover, treatment increased the bacterial
population of Akkermansia by restoring antioxidant systems in the colonic mucosa of mice. These results show a
promising pathway to design innovative and more efficient therapies against CRC based on biomimetic calcium
phosphate NPs loaded with natural products.