Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells
Metadatos
Mostrar el registro completo del ítemAutor
Florido Ruiz, Javier; Rodríguez Santana, César; Martínez Ruiz, Laura; López Rodríguez, Alba; Acuña Castroviejo, Darío; Rusanova Rusanova, Iryna; Escames Rosa, GermaineEditorial
MDPI
Materia
Melatonin Reactive oxygen species Apoptosis Mitochondria Cancer
Fecha
2022-08-20Referencia bibliográfica
Florido, J... [et al.]. Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells. Antioxidants 2022, 11, 1621. [https://doi.org/10.3390/antiox11081621]
Patrocinador
MCIN/AEI, Spain; European Commission SAF2017-85903-P ID2020-115112RB-I00; Consejeria de Innovacion, Ciencia y Empresa Junta de Andalucia P07-CTS-03135 P10-CTS-5784 CTS-101; University of Granada, Spain UCE-PP2017-05; Spanish GovernmentResumen
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. In this context, tumor cells have an altered
redox balance compared to normal cells, which can be targeted as an antitumoral therapy by ROS
levels and by decreasing the capacity of the antioxidant system, leading to programmed cell death.
Melatonin is of particular importance in the development of innovative cancer treatments due to
its oncostatic impact and lack of adverse effects. Despite being widely recognized as a pro-oxidant
molecule in tumor cells, the mechanism of action of melatonin remains unclear, which has hindered its
use in clinical treatments. The current review aims to describe and clarify the proposed mechanism of
action of melatonin inducing ROS production in cancer cells in order to propose future anti-neoplastic
clinical applications.