@misc{10481/76949,
year = {2022},
month = {8},
url = {https://hdl.handle.net/10481/76949},
abstract = {Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. In this context, tumor cells have an altered
redox balance compared to normal cells, which can be targeted as an antitumoral therapy by ROS
levels and by decreasing the capacity of the antioxidant system, leading to programmed cell death.
Melatonin is of particular importance in the development of innovative cancer treatments due to
its oncostatic impact and lack of adverse effects. Despite being widely recognized as a pro-oxidant
molecule in tumor cells, the mechanism of action of melatonin remains unclear, which has hindered its
use in clinical treatments. The current review aims to describe and clarify the proposed mechanism of
action of melatonin inducing ROS production in cancer cells in order to propose future anti-neoplastic
clinical applications.},
organization = {MCIN/AEI, Spain},
organization = {European Commission	SAF2017-85903-P	
ID2020-115112RB-I00},
organization = {Consejeria de Innovacion, Ciencia y Empresa		
Junta de Andalucia	P07-CTS-03135	
P10-CTS-5784	
CTS-101},
organization = {University of Granada, Spain	UCE-PP2017-05},
organization = {Spanish Government},
publisher = {MDPI},
keywords = {Melatonin},
keywords = {Reactive oxygen species},
keywords = {Apoptosis},
keywords = {Mitochondria},
keywords = {Cancer},
title = {Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells},
doi = {10.3390/antiox11081621},
author = {Florido Ruiz, Javier and Rodríguez Santana, César and Martínez Ruiz, Laura and López Rodríguez, Alba and Acuña Castroviejo, Darío and Rusanova Rusanova, Iryna and Escames Rosa, Germaine},
}