Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease
Metadatos
Afficher la notice complèteAuteur
González Rojo, Paula; Pérez Ramírez, Cristina; Gálvez Navas, José María; Pineda Lancheros, Laura Elena; Rojo Tolosa, Susana; Ramírez Tortosa, María Carmen; Jiménez Morales, AlbertoEditorial
MDPI
Materia
Cardiovascular disease Risk VDR Polymorphisms Biomarkers
Date
2022-08-04Referencia bibliográfica
González Rojo, P... [et al.]. Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease. Int. J. Mol. Sci. 2022, 23, 8686. [https://doi.org/10.3390/ijms23158686]
Patrocinador
ERDF funds (EU) from the Instituto de Salud Carlos III PT13/0010/0039Résumé
Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels.
In addition to environmental risk factors, genetic predisposition increases the risk; this includes
alterations in the vitamin D receptor gene (VDR). These alterations play a key role in modifying
vitamin D uptake, being able to modify its function and increasing susceptibility to cardiovascular
disorders. The aim of this study was to evaluate the association of polymorphisms in the VDR
gene and risk of CVD in a Caucasian population. A retrospective case-control study was conducted
comprising 246 CVD patients and 246 controls of Caucasian origin from Southern Spain. The
genetic polymorphisms BsmI (rs1544410), TaqI (rs731236), ApaI (rs7975232), FokI (rs2228570) and
Cdx2 (rs11568820) were determined by means of real-time polymerase chain reaction (PCR) for allelic
discrimination using TaqMan® probes. The logistic regression analysis adjusted for body mass index
and diabetes revealed that the TT genotype was associated with a higher risk of CVD in both the
genotypic model (p = 0.0430; OR = 2.30; 95% CI = 1.06–5.37; TT vs. CC) and the recessive model
(p = 0.0099; OR = 2.71; 95% CI = 1.31–6.07; TT vs. C). Haplotype analysis revealed that the haplotype
GAC (p = 0.047; OR = 0.34; 95% CI = 0.12–0.98) was associated with increased risk of CVD. The
VDR polymorphisms FokI (rs2228570) was significantly associated with the development of CVD. No
influence was observed of the VDR polymorphisms BsmI (rs1544410), TaqI (rs731236), ApaI (rs7975232)
and Cdx2 (rs11568820) on the risk of developing CVD in the patients studied.