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dc.contributor.authorGonzález Rojo, Paula
dc.contributor.authorPérez Ramírez, Cristina 
dc.contributor.authorGálvez Navas, José María
dc.contributor.authorPineda Lancheros, Laura Elena
dc.contributor.authorRojo Tolosa, Susana
dc.contributor.authorRamírez Tortosa, María Carmen 
dc.contributor.authorJiménez Morales, Alberto
dc.identifier.citationGonzález Rojo, P... [et al.]. Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease. Int. J. Mol. Sci. 2022, 23, 8686. []es_ES
dc.description.abstractCardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels. In addition to environmental risk factors, genetic predisposition increases the risk; this includes alterations in the vitamin D receptor gene (VDR). These alterations play a key role in modifying vitamin D uptake, being able to modify its function and increasing susceptibility to cardiovascular disorders. The aim of this study was to evaluate the association of polymorphisms in the VDR gene and risk of CVD in a Caucasian population. A retrospective case-control study was conducted comprising 246 CVD patients and 246 controls of Caucasian origin from Southern Spain. The genetic polymorphisms BsmI (rs1544410), TaqI (rs731236), ApaI (rs7975232), FokI (rs2228570) and Cdx2 (rs11568820) were determined by means of real-time polymerase chain reaction (PCR) for allelic discrimination using TaqMan® probes. The logistic regression analysis adjusted for body mass index and diabetes revealed that the TT genotype was associated with a higher risk of CVD in both the genotypic model (p = 0.0430; OR = 2.30; 95% CI = 1.06–5.37; TT vs. CC) and the recessive model (p = 0.0099; OR = 2.71; 95% CI = 1.31–6.07; TT vs. C). Haplotype analysis revealed that the haplotype GAC (p = 0.047; OR = 0.34; 95% CI = 0.12–0.98) was associated with increased risk of CVD. The VDR polymorphisms FokI (rs2228570) was significantly associated with the development of CVD. No influence was observed of the VDR polymorphisms BsmI (rs1544410), TaqI (rs731236), ApaI (rs7975232) and Cdx2 (rs11568820) on the risk of developing CVD in the patients studied.es_ES
dc.description.sponsorshipERDF funds (EU) from the Instituto de Salud Carlos III PT13/0010/0039es_ES
dc.rightsAtribución 4.0 Internacional*
dc.subjectCardiovascular diseasees_ES
dc.titleVitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Diseasees_ES

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Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional